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Carglumic acid - pedia, the free encyclopedia Www M Wife En Dob%C5%99%C3%ADnsko

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Bioavailability 30% Protein binding Undetermined Metabolism Partial Half life 4.3 to 9.5 hours Excretion Fecal (60%) and renal (9%, unchanged) Therapeutic considerations Licence data

EU EMEA:link

Pregnancy cat.

unknown

Legal status Routes Oral

Carglumic acid is an orphan drug, marketed by Orphan Europe under the trade name Carbaglu. Carglumic acid is used for the treatment of hyperammonaemia in patients with N-acetylglutamate synthase deficiency. The initial daily dose ranges from 100 to 250 mg/kg, adjusted thereafter to maintain normal plasma levels of ammonia.

[edit] References

Caldovic L, Morizono H, Daikhin Y, Nissim I, McCarter RJ, Yudkoff M, Tuchman M (2004). "Restoration of ureagenesis in N-acetylglutamate synthase deficiency by N-carbamylglutamate". J Pediatr 145 (4): 552–4. doi:10.1016/j.jpeds.2004.06.047. PMID 15480384.

Elpeleg O, Shaag A, Ben-Shalom E, Schmid T, Bachmann C (2002). "N-acetylglutamate synthase deficiency and the treatment of hyperammonemic encephalopathy". Ann Neurol 52 (6): 845–9. doi: wCarglumic acid - pedia, the free encyclopedia Www M Wife En Dob%C5%99%C3%ADnskot Office Hot c Hot Sex eCarglumic acid - pedia, the free encyclopedia Www M Wife En Dob%C5%99%C3%ADnskon In Public